Agrarian Science and Food Technologies

 BEZVERKhA Lyubov, teacher of the Department of Agronomy and Forestry of Zhytomyr Agro-technical College (Zhytomyr, st. Pokrovskaya, 96, e-mail: lubov_bezverxa@ukr.net)

TROHIMENKO Vita, Senior Lecturer Department of Technology for Processing and Quality of Livestock Products Zhytomyr National Agroecological University (Zhytomyr, Staryi Boulevard, 7; e-mail: trohimenkovita@ukr.net)

ZAKhARYN Viacheslav, Associate Professor of the Department of Obstetrics and Surgery Zhytomyr National Agroecological University (Zhytomyr, Staryi Boulevard, 7; e-mail: trohimenkovita@ukr.net)

It has been established that feeding to sows for 0-3 days of the sexual cycle of biologically active drugs of metabolic neurotropic action «Glutam 1M» and «Stimulin-Vet» promotes an increase in multiplicity and high fertility without a significant increase in the duration of pregnancy. A large number of scientists are searching and developing schemes for the use of various biologically active drugs for sows to stimulate their reproductive capacity, correction of metabolic status, hormonal background and obtain healthy offspring. Such drugs affect the physiological and metabolic processes, immunobiological reactivity, functions of the nervous and endocrine systems, and as a result, have a positive effect on the reproductive system of females. One of these drugs is «Glutamide 1M», the active substance of which is glutamic acid, which is a member of many biologically active drugs. Glutamic acid is a substitute for monoamino-dicarboxylic acids and plays an important role in the metabolism of most amino acids in the body, especially when synthesized from the corresponding keto-analogues and deamination. Glutamic acid converts it into harmless glutamate for nerve tissues and stimulates the oxidative processes in it. Glutamic acid decarboxylation products – gamma-aminobutyric acid (GABA) and glycine – act as neurotransmitters of the central nervous system. It is the main energy metabolite in the nerve tissue and exhibits neurotropic action. Glutamic acid is involved in energy, plastic and lipid metabolism, the synthesis of substitutable amino acids, is a source of substrates for a large number of intracellular enzymes and other biologically active substances. Stimulates glucagenesis by utilizing lactic acid in the liver to form glucose.

Stimulin-Vet is a biologically active drug of metabolic neurotropic action. It has two active ingredients: sodium glutaminate and sodium amber (sodium saccharide). One of the main active ingredients of the drug is amber acid. The absence of a negative effect in the use of amber acid was the basis for its use in the basis of complex drugs intended for the normalization of metabolic processes, the prevention and treatment of immunodeficiencies, toxicosis. Amber acid has a high adaptive, antihypoxic, antioxidant, neurotropic activity, normalizes energy metabolism and processes of biosynthesis in conditions of pathologies. An important feature of amber acid is that it does not induce xenobiotic effects, and even with relatively high doses does not have a negative effect on the body.

1. Yakobchuk, V.P., Yakobchuk, V.P., Kravets, I.V., & Rusak, O.P. (2012) Innovatsiinyi rozvytok haluzi svynarstva [Innovative development of the pig industry] Zhytomyr: Yevenok O.O. – 188 s.

2. Klymenko, L.V. (2006) Napriamky skorochennia vyrobnychoho tsyklu svynarstva v umovakh intehratsii Ukrainy v mizhnarodni ekonomichni struktury [Directions of reduction of production cycle of pig breeding in conditions of Ukraine's integration into international economic structures]. Zbirnyk naukovykh prats Vinnytskoho DAU – Collection of scientific works of Vinnytsia State Agrarian University, 27, 134-141.

3. Pokhodnia, H.S., Shypylov, Е.A., & K.K. Zalozhyn (1998). Yntensyfykatsyia vosproyzvodytelnыkh funktsyi svynomatok [Intensification of reproductive functions of sows]. Belhorod HSKhA. – Belgorod GSHA, 208.

4. Bashkeev, E. (1979) Byotekhnycheskye sposobы rehulyrovanyia vosproyzvedenyia [Biotechnical methods of regulating reproduction]. Svynovodstvo – Pig farming, 3, 36-39.

5. Yotsius, H., & Zhylynskas, H. (1981). Еffektyvnost hormonalnykh preparatov [The effectiveness of hormonal drugs]. Svynovodstvo – Pig farming, 12, 23-24.

6. Sheremeta, V.I., Bezverkha, L.N., Seba, M.V., & Trokhymenko, V.Z. (2017). Pidvyshchennia vidtvoriuvalnoi zdatnosti svynomatky pry dii preparatu Hliutam 1M [Increasing reproductive capacity of the sow with the action of the drug Glutam 1M]. Fiziolohichnyi zhurnal, Instytut fiziolohii im. O.O. Bohomoltsia Natsionalnoi Akademii Nauk Ukrainy – Physiological Journal, Institute of Physiology O.O. Bogomolets of the National Academy of Sciences of Ukraine, 63, 4, 72-79.

7. Sapiha, O.A. (2007). Aktyvizatsiia vidtvornoi zdatnosti svynomatok [Activating reproductive capacity of sows]. Tvarynnytstvo Ukrainy – Animal husbandry of Ukraine, 5, 29-30.

8. Shu Deng-qun. Jiangxi nongyo daxue xuebao / Shu Deng-qun, Peng Chun-fa, Wu Deng-kun // Acta Agr. Univ. Jiangxi. – 2002. – № 2. – P. 156-158.

9. Trohіmenko, V.Z. (2014). Biotekhnolohichnyi sposib polipshennia vidtvoriuvalnoi zdatnosti koriv [Biotechnological way to improve the reproductive capacity of cows]. Naukovyi visnyk NUBIP Ukrainy. Ser. Tekhnolohiia vyrobnytstva i pererobky produktsii tvarynnytstva - Scientific Bulletin of NUBIP of Ukraine. Sir Technology of production and processing of livestock products, 202, 298-303.