Issue №: 2(101)
У збірнику висвітлено питання підвищення продуктивності виробництва продукції сільського і рибного господарства, технології виробництва і переробки продукції тваринництва, харчових технологій та інженерії, водних біоресурсів і аквакультури
CHARACTERISTIC OF SUS SCROFA’S GENOME
Kostenko S.O., Doctor of Biological Sciences, Professor
National University of Life and Environmental Sciences of Ukraine
Sus scrofa is an important agricultural species, which has been a reliable source of protein for humanity for the last 8-10 thousand years from the time of domestication. The digestive system, kidneys, vascular structures and respiration rates of omnivorous pigs are similar to humans. Pigs are used as a model organism in the study of obesity, cardiovascular, endocrinological diseases including diabetes, alcoholism, nephropathy, as well as in the organ transplantation. They are a good object for the study of obesity, gynecological and infectious diseases in humans.
Since pigs exist in both wild and domestic populations that differ in phenotype and karyotype, the pig remains an attractive model for domestication. According to different calculations there are more than 100 breeds of pigs in the world today. The world’s population of pigs is over 1 billion. The haploid genome of Sus scrofa is 2,800 MB. The diploid genome is organized into 18 pairs of autosomes and two sex chromosomes. The results of the first sequencing of the pig’s genome, namely, that one of the sow of the Duroc breed, are presented in the ncbi database.
According to the ncbi database, the size of Sus scrofa’s genome is 2,457,910 pairs of nucleotides (it’s corresponding to the mammals’ genome, for example, 2,649,530 pairs of nucleotides in cattle). The size of the mitochondrial genome is 16,770 pairs of nucleotides (16,340 in cattle). The 1st chromosome has the largest nucleotide composition of 274,330 pairs of nucleotides, which is significantly higher than the 1st chromosome of cattle (158,340). The X-chromosome has 125,940 pairs of nucleotides, while the chromosome 18 (55,980) and the Y-chromosome (43,550) are the smallest among the autosomes.
In order to provide the international coordination, the consortium for sequencing the genome sequence of pigs (SGSC), created by the representatives of academic, government and industry organizations, has been successfully operating since September 2003.
Various resources have been developed in recent years to identify the genes associated with certain mutations and search the individual genes with quantitative traits loci (QTL).
Today, the QTL database contains data on 27,465 loci of Sus scrofa, which are associated with 663 different quantitative traits. The database is filled with data from 620 publications, it facilitates the process of comparing, verifying, finding and the most likely location of genes, as well as describes the data that can be analyzed by means of the resources from the other databases using the appropriate tools on those sites.
Animal QTLdb tools allow to compare data between the QTL/phenotype by association and comparison of these data with different genome characteristics. The Online Mendelian Inheritance in Animals (OMIA) database contains information on the cattle’s characteristics that are inherited by Mendel’s laws (phene). For April 2018, 253 characteristics of pigs were described in this database, 109 of them are considered as potential models for the researches on human diseases.
1. White S. (2011) From globalized pig breeds to capitalist pigs: a study in animals cultures and evolutionary history. Environ. Hist. ;16:94-120
2. Walters, E. M., Wolf, E., Whyte, J. J., Mao, J., Renner, S., Nagashima, H., Prather, R. S. at al. (2012). Completion of the swine genome will simplify the production of swine as a large animal biomedical model. BMC Medical Genomics, 5, 55. http://doi.org/10.1186/1755-8794-5-55
3. Rothschild, M. F., Hu, Z., & Jiang, Z. (2007). Advances in QTL Mapping in Pigs. International Journal of Biological Sciences, 3(3), 192-197.
4. Rubin, C.-J., Megens, H.-J., Barrio, A. M., Maqbool, K., Sayyab, S., Schwochow, D., Andersson, L. at al. (2012). Strong signatures of selection in the domestic pig genome. Proceedings of the National Academy of Sciences of the United States of America, 109(48), 19529–19536. http://doi.org/10.1073/pnas.1217149109
5. Groenen, M. A. M., Archibald, A. L., Uenishi, H., Tuggle, C. K., Takeuchi, Y., Rothschild, M. F., Schook, L. B. at al.(2012). Analyses of pig genomes provide insight into porcine demography and evolution. Nature, 491(7424), 393–398. http://doi.org/10.1038/nature11622
6. Gerasimov, V.I., Baranovskiy, D.I., Hohlov, A.M., Nagaevich, V.M., Ryibalko, V.P., Zasuha, Yu.V., Pohodnya, G.S. at al. (2009) Dikie i domashnie svini Monografiya / pod red. V.I.Gerasimova i D.I.Baranovskogo. Harkov: Espada [in Russia].
7. http://ref.data.fao.org/dataset?entryId=c70af091-56be-41cc-8535-92c2ae46094
8. National Center for Biotechnology Information. Retrieved from: https:// www.ncbi.nlm.nih.gov/genome/?term=pig
9. Schook, L.B., Beever, J. E., Rogers, J., Humphray, S., Archibald, A., Chardon, P., Eversole, K. at al. (2005). Swine Genome Sequencing Consortium (SGSC): A Strategic Roadmap for Sequencing The Pig Genome. Comparative and Functional Genomics, 6(4), 251–255. http://doi.org/10.1002/cfg.479
10. Humphray, S. J., Scott, C. E., Clark, R., Marron, B., Bender, C., Camm, N., Rogers, J. at al. (2007). A high utility integrated map of the pig genome. Genome Biology, 8(7), R139. http://doi.org/10.1186/gb-2007-8-7-r139
11. Archibald, A. L., Bolund, L., Churcher, C., Fredholm, M., Groenen, M. A., Harlizius, B., Schook, L. B. at al. (2010). Pig genome sequence - analysis and publication strategy. BMC Genomics, 11, 438. http://doi.org/10.1186/1471-2164-11-438
12. Jong-Joo Kim, Young I. Park (2001) Current Status of Quantitative Trait Locus Mapping in Livestock Species - Review -Asian-Australas J Anim Sci.; 14(4):587-596. https://doi.org/10.5713/ajas.2001.587
13. The Animal Quantitative Trait Loci (QTL) Database (Animal QTLdb). Retrieved from https://www.animalgenome.org/cgi-bin/QTLdb/SS/index
14. Hu, Z.-L., Park, C. A., & Reecy, J. M. (2016). Developmental progress and current status of the Animal QTLdb. Nucleic Acids Research, 44(Database issue), D827–D833. http://doi.org/10.1093/nar/gkv1233
15. Online Mendelian Inheritance in Animals (OMIA). Retrieved from http://omia.org/home/
About journal
Аnimal feeding and feed technology; current problems of animal breeding, breeding and hygiene; food safety and food processing technology; aquatic bioresources and aquaculture
Certificate of state registration of the print media: КВ № 21523-11423Р 18.08.2015
Founder of the collection: Vinnytsia National Agrarian University, Georgia Academy of Agricultural Sciences
Editor-in-Chief: Viktor Mazur, Candidate of Agricultural Sciences Associate Professor, VNAU (Vinnytsia)
Deputy editors-in-chief: Aleksidze G.M., D.Sc.(Ph.D.), academician of the Academy of agricultural sciences of Georgia; Yaremchuk O.S., D.Sc.(Ph.D.) Professor, University of Vinnitsa (Vinnytsia)
Secretary in charge: L. Kazmiruk
Editorial Board full list
Editorial board
Mazur Viktor, Candidate of Science, Associate Professor of VNAU (Editor-in-Chief);
Guram Aleksidze, Ph.D., Academician of the Academy of Agricultural Sciences Georgia (Deputy Editor-in-Chief);
Yaremchuk Oleksandr, Ph.D., Professor, VNAU (Deputy Editor-in-Chief);
Members of the Editorial Board:
Ibatullin Ildus, Ph.D., Professor, Academician, NULES;
Kaletnik Hryhoriy Ph.D. (Economics), Academician of NAAS of Ukraine, VNAU;
Zakharenko Mykola Oleksandrovych, Ph.D., Professor, NULES;
Vashakidze Archil, Ph.D., Academician, National Coordinator for Agricultural Electrification and Automation (Georgia);
Giorgadze Anatoly, Ph.D. (Engineering), Academy of Agricultural Sciences of Georgia;
Grib Josip, Ph.D, Professor of NUHPP;
Dzhaparidze Givi, Ph.D. (Economics), Academician, Vice-President of the Academy of Agricultural Sciences science of Georgia;
Georgiy Yeresko, Ph.D. (Engineering), Professor, Corresponding Member of NAAS of Ukraine, Institute of Food Resources;
Vlasenko Volodymyr, Ph.D.(Engineering), Professor of VTEI;
Kulyk Mykhaylo, Ph.D., Professor, Corresponding Member of NAAS of Ukraine, VNAU;
Kucheriaviy Vitaliy, Ph.D.(Engineering), Professor, VNAU;
Lysenko Alexander, Ph.D., Professor, Research Institute of Experimental Veterinary Science, Academy of Sciences of Belarus (Minsk);
Lyotka Halyna, Ph.D., Associate Professor of VNAU;
Mazurenko Mykola, Ph.D., (Engineering), Professor;
Polishchuk Galina, Ph.D., Associate Professor;
Sychevsky Mykola, Ph.D.(Economics), Professor, Corresponding Member of the National Academy of Sciences of Ukraine, Institute of Food Resources;
Skoromna Oksana, Ph.D., Associate Professor;
Chagelishvili Revaz, Ph.D., Academician, National Forestry Coordinator (Georgia);
Chudak Roman, Ph.D., (Engineering), Professor, VNAU;
Sheiko Ivan, Doctor of Science, Professor, Institute of Animal Science of the Academy of Sciences of Belarus (Zhodino);
Kazmyruk Larisa, Ph.D., Associate Professor of VNAU (secretary in charge).
Edition: Collection
Type of publication for the intended purpose: scientific
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Year of foundation: 2015
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Volume: 4 to 10 ppm (format A-4)
Edition language: (different languages) Ukrainian, Georgian, English, Russian
Scope and category of readers: nationwide, foreign researchers, university professors, graduate students, students and professionals of agriculture and fisheries and food production
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Agrarian Science and Food Technology Established in 1994 under the name of the Collection of Scientific Works of VSAU.
According to the Resolution of the Presidium of the Higher Attestation Commission of Ukraine of September 11, 1997, this publication has acquired the status of a professional, in which it is allowed to publish the main results of the dissertation research in the fields of "Agronomy", "Animal engineering" and "Economic Sciences".
In 2001-2014 it was published under the title "Collection of scientific works of Vinnytsia National Agrarian University".
Since 2015 it is:"Agricultural Science and Food Technologies".
Listed in the updated list of scientific professional editions of Ukraine in agricultural sciences under the name "Agrarian Science and Food Technologies" (ground: Order of the Ministry of Education and Science of Ukraine of May 16, 2016 No. 515).